Kieron Freeman has been called up to replace Chris Mepham after the Brentford defender withdrew from the Wales squad for the Nations League clash against Denmark on Friday.
Blades defender Freeman was drafted into the Wales squad for the match against the Republic of Ireland last month.
The Nottingham-born 26-year-old has played at under-17, under-19 and under-21 level for Wales but has yet to make an appearance for the senior team.
Mepham pulled out of last month’s high-profile friendly against Spain and the Nations League tie with the Republic after picking up a knock in training.
The centre-back has played four times for the Bees since the last international break, but it is understood he has suffered a recurrence of the unspecified injury that ruled him out last month.
The 20-year-old has impressed since making his international debut at the China Cup in March. He started both Nations League games against the Republic and Denmark in September.
Meanwhile, the Football Association of Wales have declared that Friday’s potential group decider at the Cardiff City Stadium is a 33,000 sell-out.
