It all kicks off on Friday night with Flint Mountain expecting a difficult test against visitors Newtown, who claimed their first league win in seven attempts last time out.
Third-place Holywell Town will look to deliver a big performance at home against Denbigh Town, whom the Wellmen defeated 2-1 away back in August.
On to Saturday when the top two are in action: second-place Airbus host Buckley Town in a Flintshire derby between two WBS League Cup semi-finalists.
Airbus have won seven of their last eight clashes with the Bucks and drew the other, so the form book certainly favours the Wingmakers, who have achieved seven league victories in a row and will want to keep leaders Llandudno in their sights.
Table-topping Tudno visit next-to-bottom Penrhyncoch, whom the Seasiders defeated 3-0 at Go Goodwins Stadium last September. Last season, Llandudno were thrashed 5-0 at Cae Baker, but an away win looks like the best call on this occasion.
A Brickfield Rangers team, which has been in freefall over recent weeks will seek revenge when they host Caersws, a side that has already beaten the Wrexham club twice this season: 2-0 in both league and cup.
Mold Alexandra need a good result at Guilsfield, but they will have to play well to pick up anything at Clos Mytton.
Rare Sunday fare is on the agenda for the Cymru North this weekend.
Hosts Rhyl 1879 are expected to get past bottom side Ruthin Town, while Gresford Athletic will want to wipe out the memory of a 3-0 loss at Holyhead Hotspur in November when they welcome the Holy Islanders to the Hollingsworth Group Stadium.
LOCK STOCK ARDAL NORTH EAST
Builth Wells drew 1-1 at Corwen last month, so can the Bulls go one better when they entertain the Edeyrnion side at Lant Fields on Saturday?
Lex XI are still desperately seeking their first league win, but may struggle to get it at home against a Dolgellau team no doubt anxious to bag a positive result after last weekend's unexpected loss at lowly Llangollen Town.
Can Llangollen build on their outstanding result against Dolgellau when they visit Llandrindod Wells? And can Panycae do the double against a Llanrhaeadr side they defeated 4-1 at home last August?
LOCK STOCK ARDAL NORTH WEST
Second-place Porthmadog will aim to cut the gap on leaders Bangor City 1876 to three points when they visit third-from-bottom CPD Y Felinheli.
After losing their unbeaten home record last weekend, NFA will surely target better fortunes on a trip to Pwllheli, a team the Rhyl outfit beat 2-1 at home in December.
Llay Welfare will look to improve on a 1-1 result at Bethesda earlier this season when they take on the Ogwen Valley hopefuls at The Ring, while Connah's Quay Town will seek a first-ever win over Llanrwst when the Conwy Valley men travel to Deeside Stadium.
Mynydd Isa have lost twice away to Prestatyn Town this season in league and cup games - can the villagers fare better at Argoed against the Seasiders?
LOCK STOCK ARDAL NORTH LEAGUE CUP QUARTER-FINALS
Three days after knocking Llangefni Town out of the FAW Amateur Trophy, CPD Dinas Bangor City 1876 meet the Ynys Mon side again in the league cup.
The Citizens have beaten Cefni three times already this season, and with a third semi-final spot up for grabs, they surely rank as favourites to see off the islanders again at Bangor City Stadium.
Cefn Albion versus Trearddur Bay has the makings of a cracking tie. If both sides reach their peak performance, this match could go all the way to penalties.
An all-Ardal North East battle between Knighton Town and CPD Rhos Aelwyd at Bryn-y-Castell could be another close one, while Llanuwchllyn versus Bow Street—two sides riding high in the ANE—might also be hard to separate.
