Tie of the round is surely the clash between Airbus UK Broughton and Holywell Town, second and third respectively in the league table, at the Hollingsworth Group Stadium.
The teams drew 0-0 in a league encounter at the same ground back in October.
This tie will bring together the current two most prolific goalscorers in Cymru North - Jamie Breese of Holywell and the Wingmakers' George Peers.
Newtown host Caersws in an all-Powys match-up at Latham Park.
The Robins will be out for revenge, having lost 1-0 at 'Sws in the league on January 1, Earlier in the campaign, Newtown won 2-1 in the reverse fixture.
Ruthin Town, unbeaten in their last three outings under new manager Colin Caton, will aim to record a first win over Buckley Town in six attempts.
Back in August, the Bucks edged a 3-2 verdict over the Vale of Clwyd side in the league.
CPD Y Rhyl 1879 welcome Guilsfield looking for a repeat of their 3-2 victory over the Powys side on away territory in August's league encounter between the pair.
Just two league matches on the menu for Saturday - Brickfield Rangers versus Denbigh Town and Flint Mountain at home to Mold Alexandra.
Brickfield, ninth in the table, will look to boost their undefeated run to five matches against a Denbigh outfit sitting eighth but without a victory in their last three fixtures.
Both Flint and Mold could do with a win, both lying in the bottom five.
ARDAL NORTH EAST
Saturday's most mouthwatering fixture is without a doubt second-place Bow Street's home tussle with leaders CPD Llanuwchllyn.
Bow, five points behind the table-toppers, have won eight of their last nine games, while Llan have not yet played this year but in their most recent engagement had their unbeaten record ended by Dolgellau.
In the first meeting of the high-flyers in August, Llanuwchllyn triumped 3-1.
Builth Wells will aim to avenge a 3-2 away loss in November at the hands of Penycae when the Bulls welcome the Wrexham-area hopefuls to Lant Fields.
Penycae were walloped 6-1 at Dolgellau last weekend, but under new manager Dan Richards have brought in some fresh talent in the January window, namely striker Domnic Deacon, Jordan Ellis, Harry Fuller, Callum Roberts and Lewis Clamp.
After winning 3-0 at Radnor Valley in November, Cefn Albion will target a double when they entertain the same opponents at The Muga.
Sixth-place Albion have just added former Corwen manager Adam Galdo to their staff to work alongside boss Jamie Hulse.
Goal hungry Dolgellau will seek a fourth straight win when they take on Corwen at Cae Marian. Dol striker Gerwyn Williams has bagged back-to-back hat-tricks and notched 21 goals this term.
Can Kerry end a run of three straight losses when they greet winless bottom team Lex XI at MTJ Dolforgan Park?
Undefeated in seven outings, Knighton Town are a decent shout to see off a Llandrindod Wells team they beat 4-2 on away turf at the end of August.
Llangollen Town versus Llanfair United has the makings of a draw, while CPD Rhos Aelwyd will seek to put the record straight at home to a Llanrhaeadr-ym-Mochnant side which beat the Wrexham team 4-2 at the Recreation Field in November.
ARDAL NORTH WEST
Unbeaten leaders CPD Dinas Bangor City 1876 can expect a good test when a Llay Miners Welfare team undefeated in 10 league matches visit Bangor City Stadium.
City have a three-point lead at the summit and have yet to lose this season in 15 league outings.
Second-place Porthmadog will be desperate to break a jinx when they host a Trearddur Bay side which has come out on top in four successive clashes between the pair.
In-form Bay have won seven of their last eight league games.
Bethesda Athletic will want to make it a double at home to next-bottom Penmaenmawr Phoenix, who they beat 4-1 at Cae Sling in September.
League top-scorer Osian Hughes will be a man to watch in Pesda colours.
After a thumping 6-1 victory at Penmaenmawr last weekend, CPD Pwllheli will take on Llanrwst United at The Rec with renewed confidence. Cian Pritchard, who scored a hat-trick for Pwll last week, is a talent to be wary of for the Conwy Valley visitors.
CPD Y Felinheli lost 1-0 at Connah's Quay Town in November, but the Cae Seilo side are unbeaten in four since and will aim to redress the balance at home to the Deesiders on Saturday.
Mynydd Isa might be hard-pressed to end a seven-match run without a victory when Llannefydd travel to Argoed Sports and Social Club.
Prestatyn Town, in their first league game under new manager Aden Shannon, will be out to turn the tables at home to a Llangefni Town team which beat the Seasiders 1-0 on Anglesey earlier this campaign.
Bottom side St Asaph City can expect a difficult hurdle at home to NFA.
FIXTURES - SATURDAY, JANUARY 17
JD CYMRU NORTH
League
Brickfield Rangers v Denbigh Town (2 pm)
Flint Mountain v Mold Alexandra (5.30 pm)
Welsh Blood Service League Cup round two (2 pm unless stated)
Airbus UK Broughton v Holywell Town
Newtown v Caersws (2.30 pm)
Ruthin Town v Buckley Town
CPD Y Rhyl 1879 v Guilsfield
LOCK STOCK ARDAL NORTH EAST (2 pm)
Bow Street v Llanuwchllyn
Builth Wells v Penycae
Cefn Albion v Radnor Valley
Dolgellau Athletic v Corwen
Kerry v Lex XI
Knighton Town v Llandrindod Wells
Llangollen Town v Llanfair United
Rhos Aelwyd v Llanrhaeadr
LOCK STOCK ARDAL NORTH WEST (2 pm unless stated)
CPD Dinas Bangor City 1876 v Llay Welfare
Bethesda Athletic v Penmaenmawr Phoenix
Mynydd Isa v CPD Llannefydd
Porthmadog v Trearddur Bay (2.30 pm)
Prestatyn Town v Llangefni Town
CPD Pwllheli v Llanrwst United
St Asaph City v NFA
CPD Y Felinheli v Connah's Quay Town
