Chambers will marshal the back line for league leaders Cardiff City as they look to protect their advantage at the summit of League One, while Wilshere arrives intent on inspiring his Luton Town side to upset the table-toppers.
Both clubs suffered relegation from the Championship last season and are now locked in the same battle to bounce straight back.
Wilshere, who took charge of Luton in mid-October, has overseen 11 victories in 24 matches so far.
A 2-1 success against Bradford City last weekend lifted the Hatters to seventh, within touching distance of the play-off positions, although they still trail Cardiff by a sizeable margin.
That gap has not dented the Luton boss’s belief.
“I don't believe that they are a better team than us and we’ll go there with the ambition to try and get three points,” said Wilshere.
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Cardiff, however, have been formidable on home soil, losing only twice in 15 league games at the Cardiff City Stadium.
Chambers has been central to that consistency, thriving in his role as captain during a campaign that has put the Bluebirds clear at the top, eight points ahead of third-placed Bolton Wanderers.
“Our place has been bouncing this year. We are doing our own thing and we are excited with every game,” said Chambers.
“Luton are a good team and I know the manager. I’ve known him for a long time. He’s a good guy and I’m looking forward to going up against him – we’ll speak after the game.
“It has been such an enjoyable season with the football we’ve been playing and the fans reaction. We want to bottle up this feeling and not let it go.”
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That sense of momentum is in stark contrast to last season’s disappointment, when Chambers endured relegation in his first year at the club after joining on a free transfer in July 2024.
Reflecting on that period, he said: “It was a very different feeling last season. Obviously, last year was my first year and it was tough. It was really tough.”
The transformation since then has been driven by head coach Brian Barry-Murphy, under whom Cardiff have lost only five league games while adopting a more adventurous style.
“Going down is never easy and it was really tough last year. But there is a completely different feel to the place now and that’s down to Brian Barry-Murphy,” Chambers explained.
“To change the mentality of a team that has gone down into a team that wants to work so hard in training and go out to win every game isn’t easy. He is a great coach and a great man-manager.
“The standard of training has lifted and has been really high. That shows in our performances on the pitch.”
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“This season's got a completely different feel to it and a lot of credit goes down to Brian for changing the mentality.
"He's done it since day one and everyone's taken to it really well.
“The football we're playing, the enthusiasm, the energy on the training ground, the fans - it's been such an enjoyable season. I think everyone would say the same.”
Competition for places has been another driving force behind Cardiff’s consistency, something the skipper openly welcomes.
“I've always enjoyed competition. It brings the best out in everyone,” he said, adding: “It keeps you at your best because you know you've got to perform to play again.”
Among those pushing him is young centre-back Dylan Lawlor, whose attitude has particularly impressed Chambers.
“He's really young, but he doesn't look it on the pitch. He's been brilliant,” said Chambers.
“The main thing is his character. He's willing to learn, willing to improve, works hard every day. That's what gets you where you want to be.”
As captain, Chambers has embraced the responsibility of guiding younger teammates.
“I have lots of conversations with the young boys. I remember when I was that age coming through and how exciting and how sort of new everything felt,” he said.
“It brings back all the feelings I had when I first broke through. I'm enjoying that with them, but also bringing my experience along as well.”
Despite the drop into League One, his commitment to Cardiff never wavered.
“When you have come from a league above people are going to say you should be doing as well as we are, but getting relegated is never easy. I never really thought about leaving.
“When I came here I said I wanted to find a club at which I could settle, feel a part of something and make memories. We are doing that this season and I am really enjoying it.”
